Our research examines how mechanobiological cues influence early human development in vitro, revealing how physical forces and tissue mechanics guide cellular organisation and differentiation. We employ biomimetic systems that replicate the unique structural and mechanical properties of the early embryonic environment, allowing us to study its critical role in regulating embryo implantation and ectopic pregnancy. By combining these engineered microenvironments with advanced imaging and functional assays, we aim to uncover the interplay between biomechanics and developmental biology in the earliest stages of human lifeĀ
Current Projects
Analysis of hatching in IVF
The Zona Pellucida's role in ectopic pregnancy
Mechanobiology and cell fate
Collaborators
Prof. Geraldine Hartshorne, University of Warwick
Prof. Jenny Nichols, University of Edinburgh